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A complete of 3 % of Lively substance is excreted in urine as unchanged Lively substance. Tapentadol is In addition metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 and also to hydroxy tapentadol (two %) by CYP2D6, that are even more metabolised by conjugation. Consequently, active compound metabolism mediated by cytochrome P450 t